Mechanosensitive Channels in Microbes
نویسندگان
چکیده
منابع مشابه
MscS-like mechanosensitive channels in plants and microbes.
The challenge of osmotic stress is something all living organisms must face as a result of environmental dynamics. Over the past three decades, innovative research and cooperation across disciplines have irrefutably established that cells utilize mechanically gated ion channels to release osmolytes and prevent cell lysis during hypoosmotic stress. Early electrophysiological analysis of the inne...
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Cell surface receptors are involved in numerous important biological processes including embryogenesis, tissue differentiation, and cellular homeostasis. Among them, mechanosensitive ion channels play an essential role in cellular functions of every cell including neurons, cardiomyocytes, and osteocytes. Here, we discuss types, roles, structures, and biophysical factors that affect the function...
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The tension-driven gating process of MscL from Mycobacterium tuberculosis, Tb-MscL, has been addressed at near-atomic detail using coarse-grained molecular dynamics simulations. To perform the simulations, a novel coarse-grained peptide model based on a thermodynamic parameterization of the amino-acid side chains has been applied. Both the wild-type Tb-MscL and its gain-of-function mutant V21D ...
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Bacterial responses to decreasing osmolality involve mechanosensitive channels. The crystal structure has been determined of the small conductance mechanosensitive channel (MscS) from Escherichia coli, providing new insights into mechanical and voltage sensing by this and other channel proteins.
متن کاملMechanosensitive ion channels
Mechanosensitive (MS) ion channels are to date the best characterized biological force-sensing systems. They present the best example of coupling protein conformations to the mechanics of the surrounding cell membrane. Studies of MS channels conducted over the last 28 years have from their serendipitous discovery and confusion about their artifactual nature to their molecular identification and...
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ژورنال
عنوان ژورنال: Annual Review of Microbiology
سال: 2010
ISSN: 0066-4227,1545-3251
DOI: 10.1146/annurev.micro.112408.134106